Towards genome-scale structure prediction for transmembrane proteins
نویسندگان
چکیده
منابع مشابه
Towards genome-scale structure prediction for transmembrane proteins.
In this paper we briefly review some of the recent progress made by ourselves and others in developing methods for predicting the structures of transmembrane proteins from amino acid sequence. Transmembrane proteins are an important class of proteins involved in many diverse biological functions, many of which have great impact in terms of disease mechanism and drug discovery. Despite their bio...
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Many sophisticated methods have been applied to the prediction of structure and function of protein sequences which are derived from the genome projects. However, difficulties of prediction for some protein types, e.g., membrane proteins, are not still resolved due to the lack of their 3D structure information. Although membrane proteins are minor fraction of the genome, the biological function...
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Membrane proteins fulfil a number of tasks in cells, including signalling, cell-cell interaction, and the transportation of molecules. The prominence of these tasks makes membrane proteins an important target for clinical drugs. Because of the decreasing price of sequencing, the number of sequences known is increasing at such a rate that manual annotations cannot compete. Here, topology predict...
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MOTIVATION A non-parametric method, based on a wavelet data-dependent threshold technique for change-point analysis, is applied to predict location and topology of helices in transmembrane proteins. A new propensity scale generated from a transmembrane helix database is proposed. RESULTS We show that wavelet change-point performs well for smoothing hydropathy and transmembrane profiles genera...
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Motivation: Transmembrane -barrel (TMB) proteins are embedded in the outer membranes of mitochondria, Gram-negative bacteria, and chloroplasts. These proteins perform critical functions, including active ion-transport and passive nutrient intake. Therefore there is a need for accurate prediction of secondary and tertiary structure of TMB proteins. Traditional homology modeling methods, however,...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2006
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2005.1804